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EHR: Drug Interaction Checks

This information is old and has been replaced by the Modified Stage 2 requirements per the Final Rule, 10/7/2015. See EHR Objective 2 -Clinical Decision Support.

EHR Stage 1: Core Measure 2
EHR Stage 2: Core Measure 6


Drug-drug and drug-allergy interaction checks must be enabled for the entire reporting period.

Exclusions Available? 

  • Stage 1: No
  • Stage 2: Yes, if you write less than 100 prescriptions during the reporting period. 



This is a Yes/No measure and not based on a percentage calculation.


EHR General Setup

Determine the method you will use for drug interaction checks:
If you will write 100 or more prescriptions during a reporting period:  Enable eRx - Comprehensive version and
only write electronic prescriptions.  Drug interaction checks are always enabled and will be automated.  See eRx Drug-Drug, Drug-Allergy Interaction Checks

If you are in stage 1 and will write less than 100 prescriptions during the reporting period: 
You have two options: 

  • Option 1:  Enable eRx - Comprehensive version with its automated drug-drug and drug-allergy interaction checks. 
  • Option 2:  Use Open Dental's drug-drug and drug-allergy interaction alerts.  They are always enabled, but you can set the behavior of alerts by adding or removing alert rules in a prescription template. If using Open Dental alerts, you will need to qualify for the e-Prescribing exclusion and write only paper Prescriptions in Open Dental.  These prescriptions will count towards the e-Prescribing (Rx) denominator, but not the numerator, thus reducing the Rx percentage.  But if you qualify and apply for the exclusion, the percentage won't matter.  Only use this option if you are certain you will write less than 100 prescriptions.
  • You should NOT use eRx - Basic version because you will not have drug interaction checks enabled for the reporting period.


Per the CMS recommendation, capture and save dated screenshots as evidence drug interaction checks were enabled for the entire reporting period.


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